Anaphylaxis



11th July 2004
This is my new website address. Please update your links.
My friend Noj has kindly created me a new guestbook. Thanks Noj!

4th April 2003
This is the first time I have edited this site since I first uploaded it on the 23rd of November 1997. I am now 20 and go to the University of New South Wales where I study Bachelor of Commerce, majoring in Actuarial Studies and Finance. I would like to take this opportunity to thank all of you who have signed my guestbook and emailed me over the years. I really appreciated and enjoyed reading your comments, however I'm afraid most of it is now lost. For some reason my guestbook and my little counter have disappeared??? This is actually the first time I have visited this page since early 2001, and it was working fine then, so I don't know what has happened to them. I wish I had saved my guestbook or at least read it more often. Well, it can't be helped. I will try and get a new guestbook going soon, but until then please excuse the dead links at the botton of the page. My HTML is extremely rusty so I could only manage updating my email address this time around. oh yeah...I also added a new counter! =)



23rd November 1997
My name is Cameron Sew Hoy, I am 14 years old and I am a Year 9 student at North Sydney Boys High School. Each year, all students from Years 7 to 9 at my School have to do a Major Science Assignment. This year I chose ‘Anaphylaxis’ as the topic for my research because I have three people in my family who suffer from allergies (my mum, my youngest sister, and myself) with my youngest sister, Lisae also suffering from anaphylaxis. I thought it would be a very interesting topic to study as I wanted to know more about this life-threatening allergic reaction.

To aid in my research I sent out 30 surveys to people situated in New South Wales, who suffered from Anaphylaxis. I was referred to them by Mrs Julianne Yeates, Vice President of F.A.C.T.S. Assoc. Inc., of which my family are also members. I was quite thrilled with my response (21), as I was unsure if people would take the time to fill it out. Results from this survey were used throughout my assignment to help me in my understanding of how different people coped with Anaphylaxis in various situations. Some of these results will be mentioned below.

Following, is an edited version of my assignment, which I hope you find both interesting and useful.....


Contents




What is Anaphylaxis?

Anaphylaxis is the most severe and potentially deadly of all allergic reactions. It is a sudden, severe allergic reaction that involves the whole body. If the condition is not treated immediately with injected adrenaline, and possibly also an antihistamine injected into a vein, or even steroids intravenously in very severe cases, the outcome can be extreme breathlessness, gross swelling of the body (particularly the wind pipe), heart failure and death. Anaphylaxis causes a constriction or narrowing of the airways and the blood vessels, resulting in difficult breathing, rapid pulse, a fall in blood pressure, and even cardiovascular collapse and shock. Anaphylaxis is a critical medical emergency requiring immediate injections of the hormone epinephrine, which opens the airways and blood vessels. It is also treated with antihistamines, and steroids, among other medications.


The general causes of Anaphylaxis.

Anaphylaxis can be the result from a number of causes:


Who is most likely to have an Anaphylactic Reaction?

Anyone who has asthma and food allergies may be at an increased risk for having a life-threatening reaction involving the respiratory tract. However, food allergy tends to occur in children under five years old, who commonly have atopic eczema and a family history of asthma and/or eczema. It is an uncommon cause of adverse reactions to food in adults. Anaphylaxis is also often experienced by people who have a history of allergies and therefore have memory cells ready to provoke an immediate and widespread allergic response as soon as an allergen is detected in the body.

From the results collected from the survey distributed to anaphylactic sufferers, 100% of the people who answered question 2,

"Does your family have a history of allergies?",
responded that their family did have a history of allergies. This may indicate that the chance of having allergies can be inherited, however other sources do not support these findings.


What happens during an Anaphylactic Reaction and how does the body try to combat the allergy?

During an anaphylactic reaction the body thinks a harmless substance is harmful and sends out an army of chemicals including histamine to combat the invader or "allergen". These chemicals are released throughout the whole body, including the lungs, mouth, eyes, throat, stomach, and skin, causing an allergic reaction in each area. The allergic reaction takes place on a cellular level. When the allergen enters the body, it stimulates the production of cells called B lymphocytes. Once the allergen locks onto the B lymphocyte, the B lymphocyte then rapidly and repeatedly divides, creating hundreds of new cells called plasma cells that release substances called antibodies or immunoglobulins in massive amounts. These antibodies attempt to render allergens harmless in a number of different ways. If the allergen produces a toxin, for instance, the antibody may be able to directly neutralise the harmful substance. Or, antibodies can force enemy microbes together into a clump, allowing other immune system cells such as T lymphocytes to rapidly destroy them.

After the crisis that stimulated their release is over, antibodies circulate in the body for some time, then die off. At the same time that activated the B lymphocytes into producing antibodies, they also produced "memory cells". These cells can immediately recognise the specific allergen that first provoked their production. When that allergen re-enters the body, memory cells quickly stimulate an immune system reaction to mount a quick response to try and destroy it as quickly as possible.


How people feel when they are about to have an Anaphylactic Reaction and what symptoms occur when this happens.

Most people who have had an allergic reaction first sense a feeling of foreboding - their body does not feel ‘right’. Early symptoms of anaphylaxis may include itchiness of palms or soles, faintness, feeling of generalised warmth, tingling, or metallic taste in the mouth, throat or chest discomfort, and breathing difficulty. Advanced symptoms of anaphylaxis may include facial swellings, hives, breathing difficulty, choking or coughing, vomiting or stomach upset, dizziness, loss of consciousness, diarrhoea, cramping and a drop in blood pressure. These symptoms can occur in as little as 5 to 15 minutes, but life-threatening reactions may progress over hours.

Here are how some people felt when they were having an anaphylactic reaction (taken from results of survey):


What people should do if they are having an Anaphylactic Reaction.

If you are having an anaphylactic reaction, get help immediately! It is critical that you avoid denying your symptoms and you should try to stop the reaction as soon as possible. You will need an epinephrine (adrenaline) injection to help stop the reaction. You must then immediately go to the nearest emergency room or hospital for treatment. Epinephrine buys you little time until they can get professional help.


What people can do to safeguard themselves against an Anaphylactic Reaction.

People can protect themselves from an anaphylactic reaction by taking the following steps:

Accidents are bound to happen. People should also take the following precautions to be sure they minimise their reaction:


What medication can be used to control and prevent Anaphylactic Reactions?

The only treatment, once anaphylaxis is established, is an injection of adrenaline which restores the blood circulation. Any other medication is too slow. Adrenaline is available via prescription in the form as an EpiPen® or AnaKit®, and a supply should be carried by the sufferer at all times. There are also other medications which can be used in less severe cases, these include steroids, antihistamines, and cortisone.


How Doctors test for Anaphylaxis on people.

If you suspect you are suffering from a serious allergic reaction, ask your doctor’s advice or an allergy clinic. You should be ready to answer a wide range of questions about your day-to-day life. Any of the following methods may be used to identify the cause of your allergy.

Case Histories
All investigations of allergy begin with a detailed case history. When you first go to an allergy clinic, the relevance of some of the information required will not always be obvious to you. However, a painstaking picture of your way of life, built up month after month, will provide valuable clues to diagnosis. Your case history would cover family history, the symptoms and their circumstances, your habits at home, your professional and leisure activities, your environment, your eating habits, and your general state of health.

Even so, tracing the cause of an individual allergy is still far from straightforward. For example, there may be a number of contributing allergens, some inhaled and others eaten. You may consult a doctor about an isolated symptom but careful questioning may eventually reveal a much more complicated picture.

Skin Tests
Skin tests involve introducing into the skin (usually behind the forearm or on the back) a small quantity of very pure allergens and in known concentrations. There are three methods which are:

In all three tests, very dilute preparations of allergens are used. In all three cases the reaction can be read after 20 minutes. If the reaction is positive, the medicine will observe a pimple, or tiny swelling, an erythema (redness) or pruritus (rash).

Blood Tests
The most common used blood test is the estimation of specific IgE (immunoglobulin E) in the blood. It involves detecting the presence of these antibodies directed against allergens present in the environment. IgE testing is carried out on a sample of blood serum taken from the patient by needle. There is no need to fast before the blood test. This method is based on the use of tiny confetti made of purified allergens. In the presence of the allergic patient’s serum, these allergens and the IgE serum will link up making an antigen-allergen complex. A very refined analysis technique will then reveal the reaction and determine how acute it is. One advantage of this method is that the patient does not have to come into direct contact with the allergen, therefore suffering less.

Inductive Tests
The principle behind the inductive test is to reproduce the symptoms of the allergic reaction by bringing the patient into contact with the suspected allergen. If the reaction occurs, it can be concluded that the allergen used is the culprit.

These induction tests are only carried out when there is a discrepancy between the case study, skin tests and the results of the biological examination (e.g. specific IgE tests). They must be carried out in special centres as their interpretation is difficult and they may involve risk.


What support is available to people with Anaphylaxis.

There are Support Groups available all around the world to assist and help people to cope with anaphylaxis. In Australia, we have the Food Anaphylactic Children Training and Support Association known as F.A.C.T.S.. The main objectives of Support Groups are to help people suffering form anaphylaxis and their families cope with the problem, and to offer advice as to how the problem should be handled. (Attached to this assignment is an information letter sent out by F.A.C.T.S. to new anaphylactic sufferers). I would also like to add that 20 out of 21 of my respondents are members of F.A.C.T.S.. It is also possible for sufferers to get information and help through the Internet. For example, The Food Allergy Network at http://www.foodallergy.org and their email address is fan@worldweb.net.


What you should do if you see someone having an Anaphylactic Shock.

If you should see someone having an anaphylactic reaction, you should attend to them immediately, as that persons life may be in danger. Here is what you should do:
  1. Lie the person down and raise the feet.
  2. Clear the airway and give oxygen by mask if available.
  3. Administer the Adrenaline auto-injector as instructed.
  4. Ring for ambulance and state clearly that the person is having an anaphylactic reaction and requires rapid transfer to hospital via Intensive Care Ambulance.


Suggestions as to how children with Anaphylaxis can still participate in normal school life.

Teachers and students should be educated about anaphylaxis and be aware that this is life threatening. Teacher and students should be aware of who the child is that has anaphylaxis, and what that person is allergic to. The teachers should also be told what to do if an anaphylactic reaction occurs at school. When teachers give out sweets as treats, they need to be aware of the child with food allergies, so as not to give allergenic foods to these children. Also, when birthday parties are celebrated in the Class-room, the child with food allergies should not miss out in the celebrations because they can not share in the food. Perhaps, the birthday child’s parent could make provisions for the person with food allergies, or the anaphylactic child’s parent could bring in some food to replace that provided by the birthday person. Children with anaphylaxis should be given the opportunity to lead as normal lives as possible, as long as others around them are aware and responsible. The School Canteen Manager and her staff also need to be educated about children who have food allergies, and explain what anaphylaxis is to them. They need to know the composition of the foods they sell, so that if a child asks, "Does it contain any dairy products?", they can answer knowledgeably. They might also carry a range of foods for people with food allergies, so that they are not discriminated against.


Precautions Anaphylactic sufferers take to prevent Anaphylaxis happening at HOME.

Overall, the response from my survey, indicated that most families make it clear to the rest of their family what food items are not allowed within the house or near the sufferer. Many people also said that they shop carefully to make sure the items do not contain the unwanted food. Here are some precautions in which anaphylactic sufferers take to prevent anaphylaxis happening at Home (taken from responses of survey):


Precautions Anaphylactic sufferers take to prevent Anaphylaxis happening at SCHOOL.

The responses from my survey showed that most parents who have anaphylactic children, make it aware to the students and teachers of the school. Teachers are also trained in what to do in such a situation. Students of the school are notified and made aware that this child is unable to tolerate particular food stuffs, and to keep that food away from the child. Many respondents also indicated that medication is kept within the school in case of an emergency. Here are some precautions in which anaphylactic sufferers take to prevent anaphylaxis happening at School (taken from responses of survey):


Precautions Anaphylactic sufferers take to prevent Anaphylaxis happening with their FRIENDS.

Many of the responses from the survey revealed that when at friend’s homes, the parents are made aware of the child’s condition and are told to take care with the handling of food. The child’s own food is taken to a new friend’s house, so as to reduce the risks. Here are some precautions in which anaphylactic sufferers take to prevent anaphylaxis happening with friends (taken from responses of survey):


Precautions Anaphylactic sufferers take to prevent Anaphylaxis happening in OTHER SITUATIONS.
(e.g. restaurants, overseas flights, shopping, etc).

Generally, the parents indicated that they took extra care when they are out with their children. They ask questions and when in doubt do not eat the food and pack their own food. Here are some precautions in which anaphylactic sufferers take to prevent anaphylaxis happening in Other Situations (taken from responses of survey):


Suggestions about ways to raise community awareness about Anaphylaxis.

Here are some suggestions as to ways in which we can raise community Awareness about anaphylaxis (suggestions compiled from results of survey):




Reference List.

Books
Brostoff, J., and Gamlin, L., (1989), The Complete Guide to Food Allergy and Intolerance, Bloomsbury publishing Limited.

Hibberd, J., (1995), The Great Allergy Detective Book, Bookman Press.

Mumby, K., (1993), The Complete Guide to Food Allergies and Environmental Illness, An Imprint of Harper Collins Publishers.

Rothfeld, G., and Levert, S., (1997), Natural Medicine for Allergies, Rodale Press, Inc.

Riches, H.R.C., (1990), Allergies, The UCB Institute of Allergy.

Smith, M., (1994), Allergies, Kyle Cathie Limited.

Steel, M., (1986), Understanding Allergies, Consumers’ Association and Hodder & Stoughton.


Pamphlets
Muñoz-Furlong, A., (1992), Just One Little Bit Can Hurt! Important Facts About Anaphylaxis, The Food Allergy Network.

Wood, R., and Muñoz-Furlong, A., (1993), Learning to Live With Food Allergies: Tips for Parents and Teens. Parent’s Guide, The Food Allergy Network.

Wood, R., (1993), Learning to Live With Food Allergies: Tips for Parents and Teens. Teen’s Guide, The Food Allergy Network.


Acknowledgements.

I would like to thank the following people for taking the time to fill out my survey:
Mr Rudi Bartl,
Ms Eileen Burke,
Mrs Noreen Clarke,
Ms Kate Clements,
Ms Lisa Donnellan,
Ms Rosemary Dwyer,
Ms Ruth Dwyer,
Mrs Kim Evans,
Ms Jennifer Hoppenbrouwer,
Ms Leah McKenzie,
Ms Leeanne Millward,
Ms Margaret Neville,
Ms Dawn Pusey,
Mrs Maria Sew Hoy,
Ms Roslyn Teblle,
Alessandro Teghini,
James Uden,
Ms Barbara Whitaker,
Ms Megan Wurth,
Mr Hung Yang,
Mrs Julianne Yeates, Vice President of F.A.C.T.S. Assos. Inc.

I would also like to especially thank Mrs Julianne Yeates, Vice President of F.A.C.T.S. Assos. Inc., who referred many of the above people to me, and gave me information, such as pamphlets and papers about anaphylaxis.




Contact me.....

If you have any comments or questions please Email Me

While you are here you can Sign or View my NEW Guestbook!

Sign Guestbook
Sign
View Guestbook
View



You are vistor since the 4th April, 2003.

Cameron
ICQ#:834763

Current ICQ status: